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The Guide of Cure Runeword in Diablo II: Resurrected Ladder


Wise Member
Mar 16, 2022
The Cure Runeword is a Helm/Shield/Weapon Runeword in Diablo II: Resurrected. In this guide, we will give you quick facts about Cure , strengths and weaknesses, best classes and specs, best Mercenary use, best socketed base items to use to create this Runeword, and hints for farming the necessary Runes.
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Overview of the Cure Runeword
Cure is one of five new mid-level Helm runewords offering 20% Faster Hit Recovery (from Shael) and +10 to Vitality (from Io). This also offers 50% Poison Length reduction and +30% Poison Resistance; Cure adds an additional 10-30% Poison Resistance on top of this. A late addition to this in the PTR was the Level 1 Cleansing Aura when equipped, which further reduces the poison duration by another 39%.
The Cure Runeword also offers an increase to maximum life, making it especially good for players or Mercenaries struggling with survivability.

Cure Strengths and Weaknesses
Strengths of the Cure Runeword:

Poison resistances is especially good for certain fights, such as Andariel at the end of Act I, Coldworm the Burrower in the bottom of the Maggot Lair, and Lilith in the Pandemonium Event. It can also be situationally useful in certain areas of Act 2 with lots of Mummies.
Easily-farmed runes accessible by early Nightmare
Decent additions to defense and maximum Life to help with overall survivability, particularly for Mercenaries.
Can be excellent for early Nightmare levels when Poison resist may be in negative numbers.
Weaknesses of the Cure Runeword:
Poison is one of the least useful resistances for "everyday" wear
A strong mid-game contender for not a lot of investment, but won't have staying power
Cure is similar to four of the five other new mid-game helms introduced for Ladder Season 3, with basic survivability improvements and a specific elemental resistance package.

Cure Recommendations
Runewords vary on their suitability for different classes and specs, as well as utility for the various Mercenaries. This next section will discuss the strengths and weaknesses of the Cure Runeword, what classes and specs can make the most out of Cure, and whether you should consider using Cure with your Mercenary follower.
Best Classes and Specs for the Cure Runeword
Any class struggling with Poison Resist or wanting a swap helm for certain fights will benefit from this Runeword. Barbarians and Druids will want to make sure to put these in class-specific helms to improve the overall stats.
Cure for Mercenaries
This may be one of the best early (and cheap) helms for your Mercenary, although the choice will be which type of resistances to pick if you decide to go with that route. Since all four types of Mercenary can wear Helms, there isn't a one "best" choice here. If your Mercenary seems to be struggling with Poison, go with this one. The Level 1 Cleansing Aura makes this even more attractive, as emanating helms are not that common.
Best Socketed Base Items for Cure
Best Socketed Items: Barbarian Helms, Druid Pelts, Crowns, Masks
Barbarians and Druids should, of course, find the best three-socketed class helms they can acquire, with the best +Skill properties available.
Helms do not have issues with weight, so you don't need to take Stamina loss into consideration. Some, however, do have rather hefty Strength requirements, with various versions of the Great Helm (Winged Helm, Spired Helm) having the highest.
For those who want to balance out Strength requirements with the best possible Defense rolls, go for Crowns (Grand Crown, Corona). In the Elite category, you can also shift to a Spired Helm if you have the 192 Strength to manage it.
For players who do not invest heavily in Strength, your only Helm choice are Masks (Mask, Death Mask, Demonhead), as these are the only ones with low strength requirements and the necessary 3 sockets.
Starting at level 52, you can also use Circlets - either a Tiara (52) or a Diadem (64). Lower-level Circlets do not have adequate Sockets. Their overall Defense is not nearly as high as Masks, which is why they're probably not the best choice. However, they have absolutely no Strength requirements and have a certain sense of style.
You can make this Runeword at any level past 35.