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Mephisto Run Farming Guide in Diablo 2


Wise Member
Mar 16, 2022
What Is a Mephisto Run?
A Mephisto run is a kill of Mephisto, one of the best bosses in the game for farming decent gear for your characters. With a Waypoint close to him, a very good loot table, and the ability to cheese him, most characters will find themselves killing Mephisto over and over again to farm most of their optimal gear before moving on to the hardest areas of the game.

Where Is Mephisto Located?
Mephisto is the end boss of Act Three, and can be found at the top left of the Durance of Hate Level 3. The fastest way to get there is to use the Durance of Hate Level 2 Waypoint and run clockwise, following the wall. For players with a solid understanding of maps, you will want to go Left of the Waypoint tile. Examples provided below of the direction you want to look for the exit tile.

Can I Do a Mephisto Run?
While the Durance of Hate Level 2 can be dangerous, most Characters can run or Teleport to Mephisto. The biggest thing to watch out for in the Durance of Hate Level 2 is the Stygian Dolls that will explode on death and deal large amounts of Damage.
Once at Mephisto, if your Character is going to fight him head on it, is important to have high Cold and Lightning Resistances. He can do extremely high Damage in a single shot and without good Resistances, this can prove deadly.
If you have a Character that can attack him from range such as a Bowazon, Sorceress, Bone Necromancer, and more then you can use the Cheese Strategy at the bottom of this kill him from afar without any concern!

What Does Mephisto Drop?
One of the main reasons for farming Mephisto is because he has such valuable loot for all characters. While you will not find the most top-end gear such as Griffon's Eye Griffon's Eye, Crown of Ages Crown of Ages, or Death's Fathom Death's Fathom, farming Mephisto will lead to massive gear gains and many best in slot items such as Harlequin Crest Harlequin Crest, Arachnid Mesh Arachnid Mesh, The Stone of Jordan The Stone of Jordan, and more.
If you are playing Solo Self-Found through the game and are struggling to get to Hell Mephisto, killing Nightmare Mephisto still can drop a lot of great items. Below are some of the best items you can find from Hell and Nightmare Mephisto, but remember there are so many more not listed here.
Hell Mephisto Best Drops
--Harlequin Crest Harlequin Crest
--Arachnid Mesh Arachnid Mesh
--Mara's Kaleidoscope Mara's Kaleidoscope
--Sandstorm Trek Sandstorm Trek
--Wizardspike Wizardspike
--Andariel's Visage Andariel's Visage
--Wisp Projector Wisp Projector
--The Reaper's Toll The Reaper's Toll
--Rainbow Facets
Nightmare Mephisto Best Drops
--Arreat's Face Arreat's Face
--The Stone of Jordan The Stone of Jordan
--Vampire Gaze Vampire Gaze
--Skullder's Ire Skullder's Ire
--Herald of Zakarum Herald of Zakarum
--War Traveler War Traveler
--Skin of the Vipermagi Skin of the Vipermagi
--Raven Frost Raven Frost
--The Oculus The Oculus
--Titan's Revenge Titan's Revenge

Other Durance of Hate Level 3 Loot
On top of killing Mephisto for great items, there are also a few other places in the Durance of Hate Level 3 to get even more loot.
---The Council Members at the entrance have very good loot tables and can be quick to kill for a higher level character. This is not recommended if your character is still very weak and trying to get start up gear, or if your character does Lightning damage, as they are Lightning Immune.
---At the very top left of the map is a single Chest. This is a Super Chest and when opened has the possibility of dropping a lot of Rare items as well as High Runes.
---On either side of Mephisto are two Racks that you can very quickly click to potentially find a solid item or a good base for a Runeword.

Fight Strategy
Mephisto is known for having extremely powerful Cold and Lightning attacks. If you are going to face him head on, having high resistances for those 2 elements will be very helpful. One of his deadliest attacks is Charged Bolt, because if your character is close to him, many of the Bolts will hit you at once and shotgun your character down.
One way to avoid such scary situations can be to cheese Mephisto. This can be done in a few places on the map with the main idea being out-ranging him and having him trapped behind some of the landscape. The easiest place to do this is the moat in the middle of the map. By dragging Mephisto to one side of it and then quickly teleporting or running to the other, he will bug out and move back and forth while you can cast a variety of skills to kill him. This is great for Sorceress with Meteor Meteor, Blizzard Blizzard, Lightning Lightning, and more. Additionally characters like Bowazon, Bone Necromancer, Trap Assassins, etc.,can have an easy time killing Mephisto while staying out of harm's way.
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